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May 13, 2021Open AccessArticle
Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life threatening syndrome of excessive immune activation. This condition can be inherited or secondary to other diseases. The therapeutic success is directly related to the rapid diagnosis with the patient who have high clinical suspicious index such as febrile illness with cytopenia, liver enzyme derangement, raised serum ferritin and low fibrinogen levels. Infection is a common trigger both in those with a genetic predisposition and...
Sep 30, 2020Open AccessArticle
Introduction: The diagnosis of sickle cell disease is clinical and biological. It is possible to reduce the morbidity and mortality linked to sickle cell disease thanks to regular clinical and biological monitoring. The objective of this study is to determine the level of knowledge and practices of health providers on the biological diagnosis and biological monitoring of homozygous sickle cell disease in the city of Kindu. Methodology: This is a cross-sectional descriptive study carried out betw...
Sep 23, 2020Open AccessArticle
Low grade B-cell non-Hodgkin lymphoma (LBNHL) is usually slow growing and most often incurable. Case 1: A 47-year-old Malay gentleman was diagnosed with relapsed Stage IV Grade 2 Follicular Lymphoma (Follicular lymphoma international prognostic index, FLIPI 2: intermediate risk). He was initially treated with 6 cycles of standard rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) polychemotherapy at first presentation and was in remission for 8 years until he relapse...
Jan 10, 2020Open AccessArticle
Acute promyelocytic leukemia (APL) is a biologically and clinically distinct variant of acute myeloid leukemia (AML), and accounts for 5 to 20 percent of all AML cases. It is a highly curable hematological malignancy with targeted therapy. Patients usually present with symptoms of the complications, typically bleeding. Intracranial bleeding with APL is rarely seen at the presentation, but more common in relapsed cases. APL is a me ...
Oct 29, 2019Open AccessArticle
Vertebral hemangiomas are benign tumour and are rarely symptomatic. Aggressive forms represent less than 1% of all cases. Medical imaging allows both diagnosis and evaluation of their aggressivity. To assess the role of radiology, embolisation, percutaneous vertebroplasty and surgery in the diagnosis and treatment of vertebral hemangiomas, we report our experience of one patient who had an age of 13 years. Sh ...
Apr 13, 2018Open AccessArticle
Background: Health care
workers especially interns may be at increased health risk due to exposure to
blood and body fluids. Objective: To determine the prevalence of occupational
exposure to blood and body fluids (EBBF) among interns at the University of Port
Harcourt Teaching hospital (UPTH). Methodology: This cross-sectional study was
carried out among interns at the UPTH. Informed written consent was obta ...
Mar 09, 2018Open AccessArticle
CD95 is a cell surface receptor involved in
apoptotic signal transmission. Deregulation of this pathway results in down
regulation of apoptosis and subsequent persistence of a malignant clone. A
single nucleotide polymorphism (SNP) resulting in guanine-to-adenine (G > A)
transition in the CD95 promoter region (position ﹣1377) is thought to reduce
stimulatory protein 1 (SP1) transcription factor binding and decrease CD95
express ...
Feb 26, 2018Open AccessArticle
Background: This study
aimed at determining the prevalence and morphological types of anaemia, among
children under-five
years, who had full blood count (FBC) investigation done at the laboratory of
the Volta regional hospital. Methodology: This was a retrospective study of
archival FBC test results data for children below 5 years in the laboratory,
between1st July to 31 ...
Feb 23, 2018Open AccessArticle
The current study retrospectively reviewed the
surgical outcomes following hip fractures in uremic patients undergoing
long-term hemodialysis and compared the results with those of geriatric
patients with osteoporotic hip fractures during 1-year period. Thirteen
complications occurred among the 21 uremic patients who underwent surgical
intervention for a hip fra ...
Jan 29, 2018Open AccessArticle
Human SIRT1 is an enzyme that deacetylates the p53 tumor
suppressor protein. It has been suggested to modulate p53-dependent functions including
DNA damage-induced cell death. Sirtuins are nicotinamide adenine dinucleotide dependent
class III histone deacetylase proteins that play a crucial role in several cellular
processes, including DNA repair, apoptosis, and lifespan. In this study, we investigated
the relationship between sir ...
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