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May 13, 2021Open    AccessArticle

Hemophagocytic Lymphohistiocytosis Secondary to Varicella Zoster with Acute Liver Failure

Satesh Ramasundram, Chong Kah Kian
Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life threatening syndrome of excessive immune activation. This condition can be inherited or secondary to other diseases. The therapeutic success is directly related to the rapid diagnosis with the patient who have high clinical suspicious index such as febrile illness with cytopenia, liver enzyme derangement, raised serum ferritin and low fibrinogen levels. Infection is a common trigger both in those with a genetic predisposition and...
Open Access Library J. Vol.8, 2021
Doi:10.4236/oalib.1107367


Sep 30, 2020Open    AccessArticle

Knowledge and Practices of Health Providers on the Diagnosis and Biological Monitoring of Sickle Cell Disease in the City of Kindu, in the East of the Democratic Republic of Congo

Antoine Lufimbo Katawandja, Aimé Abdala Kingwengwe, Etienne Shindano Mwamba
Introduction: The diagnosis of sickle cell disease is clinical and biological. It is possible to reduce the morbidity and mortality linked to sickle cell disease thanks to regular clinical and biological monitoring. The objective of this study is to determine the level of knowledge and practices of health providers on the biological diagnosis and biological monitoring of homozygous sickle cell disease in the city of Kindu. Methodology: This is a cross-sectional descriptive study carried out betw...
Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1106757


Sep 23, 2020Open    AccessArticle

Series of Low-Grade B-Cell Lymphoma: Follicular Lymphoma, Marginal Zone Lymphoma, Waldenstrom Macroglobulinemia and Mantle Cell Lymphoma

Ganesh Kasinathan
Low grade B-cell non-Hodgkin lymphoma (LBNHL) is usually slow growing and most often incurable. Case 1: A 47-year-old Malay gentleman was diagnosed with relapsed Stage IV Grade 2 Follicular Lymphoma (Follicular lymphoma international prognostic index, FLIPI 2: intermediate risk). He was initially treated with 6 cycles of standard rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) polychemotherapy at first presentation and was in remission for 8 years until he relapse...
Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1106759


Jan 10, 2020Open    AccessArticle

Acute Promeylocytic Leukemia Presenting as Fatal Intracranial Bleeding in a Rural Setting

Ng Kwang How, Satesh Ramasundram, Naganathan Pillai
Acute promyelocytic leukemia (APL) is a biologically and clinically distinct variant of acute myeloid leukemia (AML), and accounts for 5 to 20 percent of all AML cases. It is a highly curable hematological malignancy with targeted therapy. Patients usually present with symptoms of the complications, typically bleeding. Intracranial bleeding with APL is rarely seen at the presentation, but more common in relapsed cases. APL is a me
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Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1106006


Oct 29, 2019Open    AccessArticle

Aggressive Vertebral Hemangioma about a Case in Lomé

K. Adjenou, M. Diallo, L. Sonhaye, M. Amadou, M. Tchaou, L. K. Agoda
Vertebral hemangiomas are benign tumour and are rarely symptomatic. Aggressive forms represent less than 1% of all cases. Medical imaging allows both diagnosis and evaluation of their aggressivity. To assess the role of radiology, embolisation, percutaneous vertebroplasty and surgery in the diagnosis and treatment of vertebral hemangiomas, we report our experience of one patient who had an age of 13 years. Sh
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Open Access Library J. Vol.6, 2019
Doi:10.4236/oalib.1105766


Apr 13, 2018Open    AccessArticle

Occupational Exposure to Blood and Body Fluids among Interns in a Tertiary Hospital in Port Harcourt, Nigeria

Nsirimobu Ichendu Paul, Tamunopreye Jaja, Peace Ibo Opara
Background: Health care workers especially interns may be at increased health risk due to exposure to blood and body fluids. Objective: To determine the prevalence of occupational exposure to blood and body fluids (EBBF) among interns at the University of Port Harcourt Teaching hospital (UPTH). Methodology: This cross-sectional study was carried out among interns at the UPTH. Informed written consent was obta
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Open Access Library J. Vol.5, 2018
Doi:10.4236/oalib.1104122


Mar 09, 2018Open    AccessArticle

Screening of Single Nucleotide Polymorphism in CD95 (APO-1/FAS) Promoter Region (G-1377A) in Children with Acute Leukemia

Dilara Fatma Akin Bali, Didem Torun Ozkan, Ahmet Emin Kurekci, Nejat Akar
CD95 is a cell surface receptor involved in apoptotic signal transmission. Deregulation of this pathway results in down regulation of apoptosis and subsequent persistence of a malignant clone. A single nucleotide polymorphism (SNP) resulting in guanine-to-adenine (G > A) transition in the CD95 promoter region (position ﹣1377) is thought to reduce stimulatory protein 1 (SP1) transcription factor binding and decrease CD95 express
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Open Access Library J. Vol.5, 2018
Doi:10.4236/oalib.1104385


Feb 26, 2018Open    AccessArticle

Prevalence and Morphological Types of Anaemia among Children Under-Five Years in the Volta Regional Hospital of Ghana

Joseph Adu-Amankwaah, Emmanuel Alote Allotey, David Annor Kwasie, Innocent Afeke, Patrick Kwasi Owiafe, Paul Chukwuemeka Adiukwu, Orish Verner Ndudiri
Background: This study aimed at determining the prevalence and morphological types of anaemia, among children under-five years, who had full blood count (FBC) investigation done at the laboratory of the Volta regional hospital. Methodology: This was a retrospective study of archival FBC test results data for children below 5 years in the laboratory, between1st July to 31
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Open Access Library J. Vol.5, 2018
Doi:10.4236/oalib.1104351


Feb 23, 2018Open    AccessArticle

Higher Complication Rate Following Hip Fractures in Uremic Patients Undergoing Maintenance Hemodialysis: A Cohort Study

Yi-Hsun Yu, Yung-Heng Hsu, Ying-Chao Chou, I-Chuan Tseng, Wen-Lin Yeh, Chi-Chung Wu
The current study retrospectively reviewed the surgical outcomes following hip fractures in uremic patients undergoing long-term hemodialysis and compared the results with those of geriatric patients with osteoporotic hip fractures during 1-year period. Thirteen complications occurred among the 21 uremic patients who underwent surgical intervention for a hip fra
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Open Access Library J. Vol.5, 2018
Doi:10.4236/oalib.1103986


Jan 29, 2018Open    AccessArticle

The Investigation of the Apoptose Structural Effects and Mechanism in Leukemic Cells of Sirt1 Inhibitor Sirtinol

Dilara Fatma Akin, Mine Mumcuoglu, Didem Torun Ozkan, Nejat Akar, Ahmet Emin Kurekci
Human SIRT1 is an enzyme that deacetylates the p53 tumor suppressor protein. It has been suggested to modulate p53-dependent functions including DNA damage-induced cell death. Sirtuins are nicotinamide adenine dinucleotide dependent class III histone deacetylase proteins that play a crucial role in several cellular processes, including DNA repair, apoptosis, and lifespan. In this study, we investigated the relationship between sir
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Open Access Library J. Vol.5, 2018
Doi:10.4236/oalib.1104268


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