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Jun 13, 2025Open Access
Introduction: Major cognitive deficits are common in Parkinson’s disease, especially in the advanced stages. The objective of this study was to determine the profile of Parkinson’s patients with major cognitive deficits seen at the Neurosciences Clinic. Patients and Methods: This is a 3-month cross-sectional study (March-June 2022). Parkinson’s patients meeting the MDS (Movement Disorder Society) criteria were included in the study. They underwent a neuropsychol...
Jun 05, 2025Open Access
Despite Parkinson’s Disease (PD) typically being diagnosed after 80% of dopaminergic neurons are lost, evidence suggests that many patients exhibit early symptoms and frequently utilize emergency department (ED) services years before formal diagnosis. Here we examine the untapped potential of EDs in early PD recognition and intervention. Analysis of nearly 14,000 PD patients from two major healthcare systems revealed that 74% visited the ED or urgent care in the two years preceding diagnosis, ye...
May 29, 2025Open Access
Chronic inflammatory demyelinating polyneuropathy (CIDP) with nerve root hypertrophy is a relatively common association, reported in approximately 16 - 54% of cases based on imaging studies. However, it may present a diagnostic challenge, particularly in atypical clinical presentations. We report the case of a 43-year-old patient diagnosed with CIDP who presented with pyramidal syndrome in the lower limbs. Spinal MRI revealed marked hypertrophy of the nerve roots, underscoring the critical role ...
Apr 16, 2025Open Access
A 42-year-old patient with no prior medical history presented with a one-week history of an inability to close his eyelids, swelling of the cheeks, and tingling sensations in the feet. These symptoms were preceded by a flu-like illness two weeks earlier. Clinical examination revealed bilateral facial diplegia with Charles Bell’s sign, an inability to puff out the cheeks or whistle, but no facial sensory disturbances. Muscle strength was normal in all four limbs, with absent deep tendon reflexes ...
Apr 09, 2025Open Access
Background: Cluster headache (CH) is a recurrent disease, characterized by severe intensity periorbital headache associated with ipsilateral autonomic signs and symptoms; attacks may occur several times per day, for periods of weeks (so-called cluster), with a relapsing periodic pattern during the year. COVID-19 pandemic has induced many lifestyle changes on the general population, especially related to the so-called lockdown. Aim of this study was to assess the clinical evolution of cluster hea...
Mar 25, 2025Open Access
Introduction: DM has been implicated with multiple complications including diabetic cardiac autonomic neuropathy (DCAN), with a global burden ranging from 1% - 90% in type 1 DM and 20% - 73% in type 2 DM. Poor glycemic control, long duration of DM and traditional cardiovascular risk factors have been associated with the development and progression of DCAN. In Tanzania, there is limited data on DCAN burden and its associated factors. This study was conducted to raise awareness ab...
Mar 13, 2025Open Access
Introduction: Transdural spinal cord herniation is a protrusion of the spinal cord through a dehiscence of the dura mater. It generally occurs in the thoracic region (between T4 and T7). It may be idiopathic or secondary (traumatic or iatrogenic). Diagnosis, which is always made by MRI, is often delayed. Observation: This was a 45-year-old patient with a history of a traffic accident. He was consulted 14 months later for gait disorders that had been evolving for...
Feb 18, 2025Open Access
Background: Glioblastoma is the most prevalent and aggressive primary malignant brain tumor, known for its rapid growth and local invasion. While it predominantly remains within the central nervous system, extracranial metastasis is extremely rare, involving the liver, lymph nodes, thorax, spleen, and bones. Thoracic involvement is often associated with the worst prognosis. Aim: This paper presents a unique case of lung metastasis from glioblastoma, highlighting...
Jan 09, 2025Open Access
Background: Cerebellopontine (CP) angle in adults may harbor a number of tumors. The most common tumors in this location include schwannoma, meningioma, and epidermoid tumor followed by metastatic lesions. Cerebellopontine angle (CPA) is an atypical site for adult medulloblastoma (MB) with only 13 cases reported in pure extra-axial location. Cases Présentations: We report a case of 22-year-old male, both presented with headache, vomiting, ataxia Magnetic resonan...
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