|
|
Go
Sep 15, 2025Open Access
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia and is a major contributor to global morbidity and mortality. Although Mondia whitei has been traditionally used for its antidiabetic and antioxidant effects, scientific evidence supporting these claims remains limited. This study aimed to evaluate the therapeutic potential of Mondia whitei root extract in a streptozotocin (STZ)-induced diabetic Wistar rat model. Phytochemical screening of ...
Jul 28, 2025Open Access
Due to the multiple diseases in the same patients, and the multiple medications they were taking, it was necessary to formulate medications containing two or more pharmaceutical substances to reduce the patient’s dosage and, as a result, reduce side effects. In this study aspirin and clopidogrel were formulated together in a pharmaceutical dosage form that ensures the chemical and physical stability. By wet granulation method as a first layer for clopidogrel as eduragit L100 as a polymer, which ...
Mar 12, 2025Open Access
Montmorillonite, which consists essentially of clay minerals belonging to the smectite group, has a wide range of chemical and industrial uses. The chemical structure composition, the exchangeableion type, and the small crystal size of smectite are responsible for several properties, including a large chemical active surface area, a high cation exchanged capacity and interlamellar surface having usual hydratation characteristics. The present work aimed to develop an organic-clay based on montmor...
Jan 08, 2025Open Access
Infrared (IR) dyes, especially those within the near-infrared (NIR) spectrum, hold significant promise for in vivo visualization, due to their ability to access biological tissues and significantly reduce background interference from autofluorescence. Nanoparticles integrated with IR dyes have undergone extensive investigation regarding their pharmacokinetic behavior, including biodistribution patterns and clearance mechanisms. These nanoparticles exhibit a remarkable ability to prefere...
Mar 15, 2024Open Access
Background: Azadirachta indica (Neem) is a medicinal plant that is traditionally known for its antimicrobial properties. The present study was aimed to determine the bioactive components of the A. indica leaves using GC-MS. Results: Results revealed presence of 35 different active compounds in different percentage composition successions. Bioactive compounds listed include; Methenamine, Hexadecanoic acid, methyl ester; Phenol; Dodecanoic acid, ...
Jun 11, 2020Open Access
The study investigated the protective and curative effects of unripe palm kernel seeds on monosodium glutamate-induced uterine fibroid in rats. The rats were in eight experimental groups according to the time of administration of the unripe palm kernel seeds: the first four groups investigated protective effects of UPK for 28 days and the last four groups investigated the curative effects of UPK after treatment with MSG for 28 days. MSG was administered to the animals by oral gavage at a dose of...
May 08, 2020Open Access
Rosa damascena or Damask rose is an aromatic shrub-like plant which has been originated from Damascus region. This flower has been used in traditional medicine and traditional cuisine for centuries. Different extracts have been prepared from its flowers as essential oils, rose water or jams. Very recently, UNESCO has inscribed the element of the Damascus rose or Rosa damascena and associated heritage practices and craftsmanship on the UNESCO Intangible Cultural Heritage of Humanity list for its ...
Mar 05, 2018Open Access
The bioactive compounds in
methanol extract of Xylopia aethiopica fruits were determined using a combination of gas chromatography and mass
spectrometry (GC-MS). The compound identification was based on the molecular
structure, molecular mass and calculated fragments. Interpretation on mass
spectrum of GC-MS analyzer (Hewlett Packard GC-MS system) was done using ...
Feb 28, 2018Open Access
Over several decades, poly
(lactic-co-glycolic acid) (PLGA) have been widely used as Micro-and
Nano-carriers of therapeutic agents for drug delivery applications. However,
encapsulation process of therapeutic agents into PLGA Nanoparticles (NPs)
necessitates a defined step to understand the effects and interactions of
parameters involved in production process. In pharmaceutics formulations, compared
to ...
Jul 26, 2016Open Access
The present study focused on synthesizing a series of novel derivatives
of 4-aryl-1-[2-(3-benzyl-4-oxo(3H)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-ylsulphanyl)
acetyl] thiosemicarbazide 5a-d and evaluating their antitumor activity. The
structure of the synthesized compounds has been ...
Go
|
|
|
