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ISSN Print: 1748-7838

ISSN Online:

Website: https://www.nature.com/cr

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An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis

Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization

Cortical branched actin determines cell cycle progression

Structural insights into a high fidelity variant of SpCas9

Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids

LKB1 expressed in dendritic cells governs the development and expansion of thymus-derived regulatory T cells

Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis

LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition

A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis

Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection

Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate

Virus-induced accumulation of intracellular bile acids activates the TGR5-β-arrestin-SRC axis to enable innate antiviral immunity

Structures of the human spliceosomes before and after release of the ligated exon

Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins

LSECtin on tumor-associated macrophages enhances breast cancer stemness via interaction with its receptor BTN3A3

Structural basis of allosteric regulation of Tel1/ATM kinase

Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy

The molecular machinery of regulated cell death

Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry

Hormones induce the formation of luminal-derived basal cells in the mammary gland

LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity

Glycolipid iGb3 feedback amplifies innate immune responses via CD1d reverse signaling

METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation

The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes

STAT3 associates with vacuolar H+-ATPase and regulates cytosolic and lysosomal pH

A novel m6A reader Prrc2a controls oligodendroglial specification and myelination

Accurate annotation of accessible chromatin in mouse and human primordial germ cells

Structures of the human pre-catalytic spliceosome and its precursor spliceosome

Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol

A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis

A post-ingestive amino acid sensor promotes food consumption in Drosophila

The adult human testis transcriptional cell atlas

Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens

Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors

Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade

Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation

Elimination of CD4lowHLA-G+ T cells overcomes castration-resistance in prostate cancer therapy

Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating

Pyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair

Integrative single-cell analysis of transcriptome, DNA methylome and chromatin accessibility in mouse oocytes

Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis

Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS

Ubiquitination of Rheb governs growth factor-induced mTORC1 activation

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