%0 Journal Article
%T Fabrication of Poly(Aspartic Acid)-Nanogold Modified Electrode and Its Application for Simultaneous  Determination of Dopamine, Ascorbic Acid, and Uric Acid
%A Juan Li
%A Xiaoli Zhang
%J American Journal of Analytical Chemistry
%P 195-203
%@ 2156-8278
%D 2012
%I Scientific Research Publishing
%R 10.4236/ajac.2012.33028
%X A nanostructured polymer film incorporated gold nanoparticles modified electrode was fabricated. The fabrication process involved a previous electropolymerization of aspartic acid and followed by the eletrodeposition of gold nano-particles on the glassy carbon electrode. The resulting poly (aspartic acid)-nanogold modified electrode (PAA- nano-Au/GCE) was characterized by scanning electron microscopy (SEM) and electrochemical impedance spectros-copy (EIS). A higher catalytic activity was obtained to electrocatalytic oxidation of dopamine (DA), ascorbic acid (AA) and uric acid (UA) due to the enhanced peak current and well-defined peak separations compared with three, bare GCE, PAA/GCE and nano-Au/GCE. Simultaneous determination of DA, AA, and UA were studied by voltammetry. The linear range of 5.0 กม 10<sup>-7</sup> - 1.0 กม 10<sup>-4</sup> M for DA, 5.0 กม 10<sup>-6</sup> - 2.0 กม 10<sup>-3</sup> M for AA and 5.0 กม 10<sup>-6</sup> - 1.0 กม 10<sup>-3</sup> M for UA was obtained. The detection limit was calculated for DA, AA and UA as being 6.5 กม 10<sup>-8</sup> M, 5.6 กม 10<sup>-7</sup> M and 3.0 กม 10<sup>-7</sup> M, respectively (S/N = 3). The practical application of the present modified electrode was demonstrated by the determination of DA, AA and UA in calf serum and fetal calf serum samples.
%K Simultaneous Determination
%K Poly (Aspartic Acid)-Nanogold Modified Electrode
%K Dopamine
%K Ascorbic Acid
%K Uric Acid
%K Voltammetry
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=18258