%0 Journal Article
%T Synthesis of geranylhydroquinone derivatives with potencial cytotoxic activity
%A Baeza
%A Evelyn
%A Catal¨¢n
%A Karen
%A Pe£¿a-Cort¨¦s
%A Hugo
%A Espinoza
%A Luis
%A Villena
%A Joan
%A Carrasco
%A H¨¦ctor
%J Qu¨ªmica Nova
%D 2012
%I Sociedade Brasileira de Qu¨ªmica
%R 10.1590/S0100-40422012000300015
%X natural geranylhydroquinone 1 and geranyl-p-methoxyphenol 2 were prepared by electrophilic aromatic substitution (eas) reactions between geraniol and 1,4-hydroquinone or p-methoxyphenol respectively, using bf3£¿et2o as a catalyst. furthermore, natural geranylquinone 3, geranyl-1,4-dimethoxyquinone 4 and the new geranyl-4-methoxyphenyl acetate 5 were obtained by chemical transformations of 1 and 2. the compounds were evaluated for their in vitro cytotoxicity activities against cultured human cancer cells of pc-3 human prostate cancer, mcf-7 and mda-mb-231 breast carcinoma, and dermal human fibroblasts dhf. ic50 values were in the ¦̀m range.
%K synthesis
%K geranylhydroquinones
%K cytotoxic activity.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0100-40422012000300015&lng=en&nrm=iso&tlng=en