%0 Journal Article
%T Complex segregation analysis of 1,792 cleft lip and palate families in South America: 1967-1997
%A Vieira
%A Alexandre Rezende
%A Romitti
%A Paul Anthony
%A Orioli
%A I¨ºda Maria
%A Castilla
%A Eduardo Enrique
%J Pesquisa Odontol¨®gica Brasileira
%D 2003
%I Scientific Electronic Library Online
%R 10.1590/S1517-74912003000200012
%X although several studies have demonstrated familial aggregation of nonsyndromic cleft lip with or without cleft palate (cl/p), its model of inheritance remains uncertain. we report the results of complex segregation analysis performed in south american families with a newborn affected with cl/p. families of 1,792 consecutive newborns affected with cl/p and registered during the period 1967 to 1997 were studied. a model that did not include a major locus was the best-fitting model for cl/p families. this result is in agreement with previous studies which showed a significant association of several putative susceptibility loci and cl/p, indicating that the genes involved in cl/p are likely to have only a very modest impact on disease risk.
%K cleft palate
%K craniofacial abnormalities
%K abnormalities
%K polygenic inheritance.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1517-74912003000200012&lng=en&nrm=iso&tlng=en