%0 Journal Article
%T Superinfecting microorganisms in patients under treatment with cyclosporin-A and its correlation to gingival overgrowth
%A Romito
%A Giuseppe Alexandre
%A Lotufo
%A Roberto Fraga Moreira
%A Saraiva
%A Luciana
%A Pustiglioni
%A Alessandro Nautili
%A Pustiglioni
%A Francisco Em¨ªlio
%A Stolf
%A Noedir Ant£¿nio Groppo
%J Pesquisa Odontol¨®gica Brasileira
%D 2003
%I Scientific Electronic Library Online
%R 10.1590/S1517-74912003000100007
%X the aim of this study was to identify the presence of superinfecting microorganisms (gram-negative enteric rods and candida sp.) in heart transplant patients and correlate this with gingival overgrowth. thirty patients (10 females, 20 males - mean age 45 years) were examined. all were under cyclosporin-a (csa) therapy. patients who had taken any antibiotics 3 months prior the study or had been submitted to periodontal therapy were not enrolled. patients were required to have at least 6 teeth. the plaque index (pi), gingival index (gi), pocket depth (pd) and clinical attachment level (cal) were recorded. microbiological samples were taken from sulcus/pocket (s/p) and from stimulated saliva (ss) and submitted to analysis. patients were divided into two groups: the ones with gingival overgrowth (go) and those without gingival overgrowth (wgo). after statistical analysis (chi-square test, student's t-test, fisher test, p < 0.05), we concluded that there was no statistical difference between groups in the parameters of gender, csa dosage, time since transplantation, pi, gi, pd and cal. gram-negative rods from either the sulcus/pocket or saliva samples were not found. candida sp. was detected (s/p - 30% and ss - 30%). stimulated saliva samples analysis determined that the presence of candida sp. was associated with patients without gingival overgrowth.
%K cyclosporine-a
%K periodontics
%K superinfection
%K gingival hyperplasia.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1517-74912003000100007&lng=en&nrm=iso&tlng=en