%0 Journal Article %T Estudio retrospectivo en pacientes con diagn車stico de carcinoma de pulm車n no microc赤tico estadio avanzado tratados con la combinaci車n gemcitabina y vinorelbina: valoraci車n de la eficacia terap谷utica y factores pron車sticos %A Luque %A M. %A Esteban %A E. %A Villanueva %A N. %A Corral %A N. %A Jim谷nez %A P. %A Capel芍n %A M. %A Llorente %A B. %A Crespo %A G. %A Berros %A J. P. %A Lacave %A A. J. %J Oncolog赤a (Barcelona) %D 2007 %I Scientific Electronic Library Online %R 10.4321/S0378-48352007000200003 %X introduction: gemcitabine (g), vinorelbine (v) and their combination (gv) have shown to be useful in patients with non-small cell lung cancer (nsclc). the purpose of this study is to confirm the activity of gv administration and to identify prognostic factors related with the clinical outcome. methods: a retrospective analysis was carried out in relation to 144 patients with nscl treated between october 1996 and april 2005 with g (1000-1250 mg/m2) + v (25-30 mg/m2) both administered on days 1 and 8 every three weeks. results: treatment was well tolerated, grade 3-4 neutropenia being registered as the worse toxic effect in 18% cases, including 7% of neutropenic fever. the objective response rate was 36.8% (95% ci: 28.9-44.7) and the median progression free survival and overall survival rates were 21 (18-25) and 33 (26-40) weeks respectively. in multivariate analysis only the histology of adenocarcinoma (hr 3; p<0.001), less than two metastatic sites (hr 1.7; p<0.02) and karnofsky index (ki) above 70% (hr 1.5; p<0.02) showed a significant association with longer survival. conclusion: the gv combination therapy is well tolerated and active in patients with advanced nsclc. the histology of adenocarcinoma, less than two metastatic sites and ki above 70% were identified as independent variables related with longer survival. %K non-small cell lung cancer %K gemcitabine %K vinorelbine %K prognostic factors. %U http://scielo.isciii.es/scielo.php?script=sci_abstract&pid=S0378-48352007000200003&lng=en&nrm=iso&tlng=en