%0 Journal Article
%T Low-Abundance HIV Drug-Resistant Viral Variants in Treatment-Experienced Persons Correlate with Historical Antiretroviral Use
%A Thuy Le
%A Jennifer Chiarella
%A Birgitte B. Simen
%A Bozena Hanczaruk
%A Michael Egholm
%A Marie L. Landry
%A Kevin Dieckhaus
%A Marc I. Rosen
%A Michael J. Kozal
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0006079
%X It is largely unknown how frequently low-abundance HIV drug-resistant variants at levels under limit of detection of conventional genotyping (<20% of quasi-species) are present in antiretroviral-experienced persons experiencing virologic failure. Further, the clinical implications of low-abundance drug-resistant variants at time of virologic failure are unknown.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006079