%0 Journal Article
%T The Sedating Antidepressant Trazodone Impairs Sleep-Dependent Cortical Plasticity
%A Sara J. Aton
%A Julie Seibt
%A Michelle C. Dumoulin
%A Tammi Coleman
%A Mia Shiraishi
%A Marcos G. Frank
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0006078
%X Recent findings indicate that certain classes of hypnotics that target GABAA receptors impair sleep-dependent brain plasticity. However, the effects of hypnotics acting at monoamine receptors (e.g., the antidepressant trazodone) on this process are unknown. We therefore assessed the effects of commonly-prescribed medications for the treatment of insomnia (trazodone and the non-benzodiazepine GABAA receptor agonists zaleplon and eszopiclone) in a canonical model of sleep-dependent, in vivo synaptic plasticity in the primary visual cortex (V1) known as ocular dominance plasticity.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006078