%0 Journal Article
%T CFH, C3 and ARMS2 Are Significant Risk Loci for Susceptibility but Not for Disease Progression of Geographic Atrophy Due to AMD
%A Hendrik P. N. Scholl
%A Monika Fleckenstein
%A Lars G. Fritsche
%A Steffen Schmitz-Valckenberg
%A Arno G£¿bel
%A Christine Adrion
%A Christine Herold
%A Claudia N. Keilhauer
%A Friederike Mackensen
%A Andreas M£¿£¿ner
%A Daniel Pauleikhoff
%A Andreas W. A. Weinberger
%A Ulrich Mansmann
%A Frank G. Holz
%A Tim Becker
%A Bernhard H. F. Weber
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0007418
%X Age-related macular degeneration (AMD) is a prevalent cause of blindness in Western societies. Variants in the genes encoding complement factor H (CFH), complement component 3 (C3) and age-related maculopathy susceptibility 2 (ARMS2) have repeatedly been shown to confer significant risks for AMD; however, their role in disease progression and thus their potential relevance for interventional therapeutic approaches remains unknown.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0007418