%0 Journal Article
%T New Antibiotic Molecules: Bypassing the Membrane Barrier of Gram Negative Bacteria Increases the Activity of Peptide Deformylase Inhibitors
%A Laurent Mamelli
%A Sylvain Petit
%A Jacqueline Chevalier
%A Carmela Giglione
%A Aur¨Ślie Lieutaud
%A Thierry Meinnel
%A Isabelle Artaud
%A Jean-Marie Pag¨¨s
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0006443
%X Multi-drug resistant (MDR) bacteria have become a major concern in hospitals worldwide and urgently require the development of new antibacterial molecules. Peptide deformylase is an intracellular target now well-recognized for the design of new antibiotics. The bacterial susceptibility to such a cytoplasmic target primarily depends on the capacity of the compound to reach and accumulate in the cytosol.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006443