%0 Journal Article
%T Express£¿o do complexo de histocompatilidade principal de classe I (MHC I) no sistema nervoso central: plasticidade sin¨¢ptica e regenera£¿£¿o
%A Zanon
%A Renata Graciele
%A Emirandetti
%A Amanda
%A Sim£¿es
%A Gustavo Ferreira
%A Freria
%A Camila Marques
%A Vict¨®rio
%A Sheila Cristina
%A Cartarozzi
%A Luciana Politti
%A Barbizan
%A Roberta
%A Oliveira
%A Alexandre Leite Rodrigues de
%J Coluna/Columna
%D 2010
%I Sociedade Brasileira de Coluna (SBC)
%R 10.1590/S1808-18512010000200017
%X it has been recently demonstrated that the major histocompatibility complex of class i (mhc i) expressed in the central nervous system (cns) does not only function as a molecule of the immune system, but also plays a role in the synaptic plasticity. the expression of mhc i influences the intensity and selectivity of elimination of synapses apposed to neurons that were subjected to lesion, besides influencing the reactivity of neighboring glial cells. mhc i expression and the degree of synaptic rearrangement and glial response after injury correlate with differences in the regenerative potential and functional recovery of isogenic mice strains. in this way, the new aspects regarding mhc i functions in the cns may guide further studies aiming at searching the involvement of mch i in neurologic disorders, as well as the development of new therapeutic strategies.
%K major histocompatibility complex
%K spinal cord
%K axotomy
%K neuronal plasticity
%K synapses
%K axons.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1808-18512010000200017&lng=en&nrm=iso&tlng=en