%0 Journal Article
%T Chest computed tomography findings in severe influenza pneumonia occurring in neutropenic cancer patients
%A Rodrigues
%A Rosana Souza
%A Marchiori
%A Edson
%A Bozza
%A Fernando A.
%A Pitrowsky
%A Melissa Tassano
%A Velasco
%A Eduardo
%A Soares
%A M¨¢rcio
%A Salluh
%A Jorge I. F.
%J Clinics
%D 2012
%I Faculdade de Medicina / USP
%R 10.6061/clinics/2012(04)03
%X objective: to describe the chest computed tomography findings for severe influenza h1n1 infection in a series of hospitalized neutropenic cancer patients. methods: we performed a retrospective systematic analysis of chest computed tomography scans for eight hospitalized patients with fever, neutropenia, and confirmed diagnoses of influenza h1n1. the clinical data had been prospectively collected. results: six of eight patients (75%) developed respiratory failure and required intensive care. prolonged h1n1 shedding was observed in the three mechanically ventilated patients, and overall hospital mortality in our series was 25%. the most frequent computed tomography findings were ground-glass opacity (all patients), consolidation (7/8 cases), and airspace nodules (6/8 cases) that were frequently moderate or severe. other parenchymal findings were not common. five patients had features of pneumonia, two had computed tomography findings compatible with bronchitis and/or bronchiolitis, and one had tomographic signs of chronicity. conclusion: in this series of neutropenic patients with severe influenza h1n1 infection, chest computed tomography demonstrated mainly moderate or severe parenchymatous disease, but bronchiolitis was not a common feature. these findings associated with febrile neutropenia should elicit a diagnosis of severe viral infection.
%K h1n1
%K viral pneumonia
%K neutropenia
%K cancer
%K computed tomography.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1807-59322012000400003&lng=en&nrm=iso&tlng=en