%0 Journal Article
%T Comprehensive Identification and Modified-Site Mapping of S-Nitrosylated Targets in Prostate Epithelial Cells
%A Ying Wai Lam
%A Yong Yuan
%A Jared Isaac
%A C. V. Suresh Babu
%A Jarek Meller
%A Shuk-Mei Ho
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0009075
%X Although overexpression of nitric oxide synthases (NOSs) has been found associated with prostate diseases, the underlying mechanisms for NOS-related prostatic diseases remain unclear. One proposed mechanism is related to the S-nitrosylation of key regulatory proteins in cell-signaling pathways due to elevated levels of NO in the prostate. Thus, our primary objective was to identify S-nitrosylated targets in an immortalized normal prostate epithelial cell line, NPrEC.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009075