%0 Journal Article %T Sulfatides Partition Disabled-2 in Response to Platelet Activation %A Karen E. Drahos %A John D. Welsh %A Carla V. Finkielstein %A Daniel G. S. Capelluto %J PLOS ONE %D 2012 %I Public Library of Science (PLoS) %R 10.1371/journal.pone.0008007 %X Platelets contact each other at the site of vascular injury to stop bleeding. One negative regulator of platelet aggregation is Disabled-2 (Dab2), which is released to the extracellular surface upon platelet activation. Dab2 inhibits platelet aggregation through its phosphotyrosine-binding (PTB) domain by competing with fibrinogen for ¦ÁIIb¦Â3 integrin receptor binding by an unknown mechanism. %U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0008007