%0 Journal Article
%T Protective Role of R-spondin1, an Intestinal Stem Cell Growth Factor, against Radiation-Induced Gastrointestinal Syndrome in Mice
%A Payel Bhanja
%A Subhrajit Saha
%A Rafi Kabarriti
%A Laibin Liu
%A Namita Roy-Chowdhury
%A Jayanta Roy-Chowdhury
%A Rani S. Sellers
%A Alan A. Alfieri
%A Chandan Guha
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0008014
%X Radiation-induced gastrointestinal syndrome (RIGS) results from a combination of direct cytocidal effects on intestinal crypt and endothelial cells and subsequent loss of the mucosal barrier, resulting in electrolyte imbalance, diarrhea, weight loss, infection and mortality. Because R-spondin1 (Rspo1) acts as a mitogenic factor for intestinal stem cells, we hypothesized that systemic administration of Rspo1 would amplify the intestinal crypt cells and accelerate the regeneration of the irradiated intestine, thereby, ameliorating RIGS.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0008014