%0 Journal Article
%T LIGHT Induces Distinct Signals to Clear an AAV-Expressed Persistent Antigen in the Mouse Liver and to Induce Liver Inflammation
%A Michael L. Washburn
%A Grigoriy I. Kovalev
%A Ekaterina Koroleva
%A Yang-Xin Fu
%A Lishan Su
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0010585
%X Infection with adeno-associated virus (AAV) vector with liver tropism leads to persistent expression of foreign antigens in the mouse liver, with no significant liver inflammation or pathology. This provides a model to investigate antigen persistence in the liver and strategies to modulate host immunity to reduce or clear the foreign antigen expressed from AAV vector in the liver.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0010585