%0 Journal Article
%T Examination of Apoptosis Signaling in Pancreatic Cancer by Computational Signal Transduction Analysis
%A Felix R¨¹ckert
%A Gihan Dawelbait
%A Christof Winter
%A Arndt Hartmann
%A Axel Denz
%A Ole Ammerpohl
%A Michael Schroeder
%A Hans Konrad Schackert
%A Bence Sipos
%A G¨¹nter Kl£¿ppel
%A Holger Kalthoff
%A Hans-Detlev Saeger
%A Christian Pilarsky
%A Robert Gr¨¹tzmann
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0012243
%X Pancreatic ductal adenocarcinoma (PDAC) remains an important cause of cancer death. Changes in apoptosis signaling in pancreatic cancer result in chemotherapy resistance and aggressive growth and metastasizing. The aim of this study was to characterize the apoptosis pathway in pancreatic cancer computationally by evaluation of experimental data from high-throughput technologies and public data bases. Therefore, gene expression analysis of microdissected pancreatic tumor tissue was implemented in a model of the apoptosis pathway obtained by computational protein interaction prediction.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012243