%0 Journal Article
%T CRY2 Is Associated with Rapid Cycling in Bipolar Disorder Patients
%A Louise K. Sj£¿holm
%A Lena Backlund
%A Emarndeena Haji Cheteh
%A Inger R£¿mer Ek
%A Louise Fris¨¦n
%A Martin Schalling
%A Urban £¿sby
%A Catharina Lavebratt
%A Pernilla Nikamo
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0012632
%X Bipolar disorder patients often display abnormalities in circadian rhythm, and they are sensitive to irregular diurnal rhythms. CRY2 participates in the core clock that generates circadian rhythms. CRY2 mRNA expression in blood mononuclear cells was recently shown to display a marked diurnal variation and to respond to total sleep deprivation in healthy human volunteers. It was also shown that bipolar patients in a depressive state had lower CRY2 mRNA levels, nonresponsive to total sleep deprivation, compared to healthy controls, and that CRY2 gene variation was associated with winter depression in both Swedish and Finnish cohorts.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012632