%0 Journal Article
%T Nucleo-Cytoplasmic Localization Domains Regulate Kr¨¹ppel-Like Factor 6 (KLF6) Protein Stability and Tumor Suppressor Function
%A Estefan¨ªa Rodr¨ªguez
%A Nana Aburjania
%A Nolan M. Priedigkeit
%A Analisa DiFeo
%A John A. Martignetti
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0012639
%X The tumor suppressor KLF6 and its oncogenic cytoplasmic splice variant KLF6-SV1 represent a paradigm in cancer biology in that their antagonistic cancer functions are encoded within the same gene. As a consequence of splicing, KLF6-SV1 loses both the C-terminus C2H2 three zinc finger (ZF) domain, which characterizes all KLF proteins, as well as the adjacent 5¡ä basic region (5BR), a putative nuclear localization signal (NLS). It has been hypothesized that this NLS is a functional domain critical to direct the distinct subcellular localization of the tumor suppressor and its splice variant.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012639