%0 Journal Article
%T The Mechanism of Release of P-TEFb and HEXIM1 from the 7SK snRNP by Viral and Cellular Activators Includes a Conformational Change in 7SK
%A Brian J. Krueger
%A Katayoun Varzavand
%A Jeffrey J. Cooper
%A David H. Price
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0012335
%X The positive transcription elongation factor, P-TEFb, is required for the production of mRNAs, however the majority of the factor is present in the 7SK snRNP where it is inactivated by HEXIM1. Expression of HIV-1 Tat leads to release of P-TEFb and HEXIM1 from the 7SK snRNP in vivo, but the release mechanisms are unclear.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012335