%0 Journal Article
%T Paeonol Oxime Inhibits bFGF-Induced Angiogenesis and Reduces VEGF Levels in Fibrosarcoma Cells
%A Hyo-Jeong Lee
%A Seung-Ae Kim
%A Hyo-Jung Lee
%A Soo-Jin Jeong
%A Ihn Han
%A Ji Hoon Jung
%A Eun-Ok Lee
%A Shudong Zhu
%A Chang-Yan Chen
%A Sung-Hoon Kim
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0012358
%X We previously reported the anti-angiogenic activity of paeonol isolated from Moutan Cortex. In the present study, we investigated the negative effect of paeonol oxime (PO, a paeonol derivative) on basic fibroblast growth factor (bFGF)-mediated angiogenesis in human umbilical vein endothelial cells (HUVECs) (including tumor angiogenesis) and pro-survival activity in HT-1080 fibrosarcoma cell line.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012358