%0 Journal Article
%T A Novel Histone Deacetylase Inhibitor Exhibits Antitumor Activity via Apoptosis Induction, F-Actin Disruption and Gene Acetylation in Lung Cancer
%A Yen-An Tang
%A Wei-Ling Wen
%A Jer-Wei Chang
%A Tzi-Tang Wei
%A Yi-Hung Carol Tan
%A Santosh Salunke
%A Chien-Tien Chen
%A Ching-Shih Chen
%A Yi-Ching Wang
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0012417
%X Lung cancer is the leading cause of cancer mortality worldwide, yet the therapeutic strategy for advanced non-small cell lung cancer (NSCLC) is limitedly effective. In addition, validated histone deacetylase (HDAC) inhibitors for the treatment of solid tumors remain to be developed. Here, we propose a novel HDAC inhibitor, OSU-HDAC-44, as a chemotherapeutic drug for NSCLC.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012417