%0 Journal Article
%T Immunoglobulin E and systemic lupus erythematosus
%A Atta
%A A.M.
%A Sousa
%A C.P.
%A Carvalho
%A E.M.
%A Sousa-Atta
%A M.L.B.
%J Brazilian Journal of Medical and Biological Research
%D 2004
%I Associa??o Brasileira de Divulga??o Cient¨ªfica
%R 10.1590/S0100-879X2004001000008
%X systemic lupus erythematosus (sle) is an autoimmune disease characterized by intense polyclonal production of autoantibodies and circulating immune complexes. some reports have associated sle with a th2 immune response and allergy. in the present study 21 female patients with sle were investigated for total ige and ige antibodies to dust house aeroallergens by an automated enzyme-linked fluorescent assay, and were also evaluated for antinuclear ige autoantibodies by a modified indirect immunofluorescence test using hep-2 cells as antigen substrate. additionally, immunocapture elisa was used to investigate serum anti-ige igg autoantibodies. serum ige above 150 iu/ml, ranging from 152 to 609 iu/ml (median = 394 iu ige/ml), was observed in 7 of 21 sle patients (33%), 5 of them presenting proteinuria, urinary cellular casts and augmented production of anti-dsdna antibodies. while only 2 of 21 sle patients (9.5%) were positive for ige antibodies to aeroallergens, all 10 patients with respiratory allergy (100%) from the atopic control group (3 males and 7 females), had these immunoglobulins. sle patients and healthy controls presented similar anti-ige igg autoantibody titers (x = 0.37 ¡À 0.20 and 0.34 ¡À 0.18, respectively), differing from atopic controls (0.94 ¡À 0.26). antinuclear ige autoantibodies were detected in 17 of 21 (81%) sera from sle patients, predominating the fine speckled pattern of fluorescence, that was also observed in igg-ana. concluding, sle patients can present increased ige levels and antinuclear ige autoantibodies without specific clinical signs of allergy or production of antiallergen ige antibodies, excluding a possible association between sle and allergy.
%K systemic lupus erythematosus
%K antinuclear ige antibody
%K allergy
%K igg anti-ige
%K ige.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0100-879X2004001000008&lng=en&nrm=iso&tlng=en