%0 Journal Article
%T Effect of chronic fish oil supplementation on renal function of normal and cachectic rats
%A Fernandez
%A R.
%A Piechnik
%A J.
%A Fabris
%A R.
%A Malnic
%A G.
%A Fernandes
%A L.C.
%J Brazilian Journal of Medical and Biological Research
%D 2004
%I Associa??o Brasileira de Divulga??o Cient¨ªfica
%R 10.1590/S0100-879X2004001000006
%X in the present study we determined the effect of chronic diet supplementation with n-3 pufa on renal function of healthy and cachectic subjects by providing fish oil (1 g/kg body weight) to female rats throughout pregnancy and lactation and then to their offspring post-weaning and examined its effect on renal function parameters during their adulthood. the animals were divided into four groups of 5-10 rats in each group: control, control supplemented with fish oil (p), cachectic walker 256 tumor-bearing (w), and w supplemented with fish oil (wp). food intake was significantly lower in the w group compared to control (12.66 ¡À 4.24 vs 25.30 ¡À 1.07 g/day). treatment with fish oil significantly reversed this reduction (22.70 ¡À 2.94 g/day). tumor growth rate was markedly reduced in the p group (16.41 ¡À 2.09 for wp vs 24.06 ¡À 2.64 g for w). wp group showed a significant increase in mean glomerular filtration rate compared to p and control (1.520 ¡À 0.214 ml min-1 kg body weight-1; p < 0.05). tumor-bearing groups had low urine osmolality compared to control rats. the fractional sodium excretion decreased in the w group compared to control (0.43 ¡À 0.16 vs 2.99 ¡À 0.87%; p < 0.05), and partially recovered in the wp group (0.90 ¡À 0.20%). in summary, the chronic supplementation with fish oil used in this study increased the amount of fat in the diet by only 0.1%, but caused remarkable changes in tumor growth rate and cachexia, also showing a renoprotective function.
%K fish oil supplementation
%K renal function
%K cachexia
%K walker 256 tumor
%K sodium excretion
%K glomerular filtration rate.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0100-879X2004001000006&lng=en&nrm=iso&tlng=en