%0 Journal Article
%T Lipid and acute-phase protein alterations in HIV-1 infected patients in the early stages of infection: correlation with CD4+ lymphocytes
%A Treitinger
%A Ar¨ªcio
%A Spada
%A Celso
%A Silva
%A Laura Maria D. da
%A Hermes
%A Elizabeth Martins
%A Amaral
%A Jorge Ant£¿nio
%A Abdalla
%A Dulcineia Saes Parra
%J Brazilian Journal of Infectious Diseases
%D 2001
%I Brazilian Society of Infectious Diseases
%R 10.1590/S1413-86702001000400005
%X lipid and acute-phase protein alterations have been described in various infection diseases, and they have been recorded during the early stages of hiv infection. lipid and acute-phase protein profiles also have been correlated with cellular immunological abnormalities. to document these correlations during hiv infection, we studied 75 hiv-infected patients and 26 hiv-negative controls. patients were classified according to the criteria proposed by the walter reed army institute: as wr-1 (cd4 lymphocytes, 1154 ¡À 268/mm3), wr-2 (cd4, 793 ¡À 348/mm3) and wr3/4 (cd4, 287¡À75 mm3). triglycerides, total cholesterol and hdl-cholesterol concentrations were measured by enzymatic methods. immunoglobulins (iga and igg) and acute-phase proteins (haptoglobin, a1-acid glycoprotein, c-reactive protein and transferrin) were determined by immunonephelometry. haptoglobin levels were significantly increased in hiv-positive patients and correlated with the progression of hiv-infection (control<wr1<wr2<wr3/4). wr-2 and wr-3/4 patients had lower total cholesterol, hdl-cholesterol, and albumin concentrations, however, a1-acid glycoprotein and iga levels were higher, when compared to hiv-negative controls. elevated triglyceride levels (1.51¡À0.75 mmol/l) were found only in wr3/4 patients, when compared to the control individuals (1.05¡À0.04 mmol/l). no differences were found in transferrin and c-reactive protein concentrations among the studied groups. cd4+ lymphocyte counts were inversely correlated with triglycerides, iga, a1-acid glycoprotein and haptoglobin, and they were positively correlated with albumin, total cholesterol and hdl-cholesterol. multiple linear regression analysis showed that increased haptoglobin and iga levels were the best predictive variables of a decreasing cd4+ lymphocyte count. in conclusion, our data showed that: 1) a decrease in total cholesterol, hdl-cholesterol and albumin levels occurred earlier than hypertriglyceridemia in the course of hiv infection; 2) incr
%K hiv
%K cd4+
%K triglycerides
%K iga
%K a1-acid glycoprotein
%K haptoglobin.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1413-86702001000400005&lng=en&nrm=iso&tlng=en