%0 Journal Article
%T MTP -493G/T gene polymorphism is associated with steatosis in hepatitis C-infected patients
%A Siqueira
%A E.R.F.
%A Oliveira
%A C.P.M.S.
%A Correa-Giannella
%A M.L.
%A Stefano
%A J.T.
%A Cavaleiro
%A A.M.
%A Fortes
%A M.A.H.Z.
%A Muniz
%A M.T.C.
%A Silva
%A F.S.
%A Pereira
%A L.M.M.B.
%A Carrilho
%A F.J.
%J Brazilian Journal of Medical and Biological Research
%D 2012
%I Associa??o Brasileira de Divulga??o Cientšªfica
%R 10.1590/S0100-879X2011007500160
%X the reduction of hepatic microsomal transfer protein (mtp) activity results in fatty liver, worsening hepatic steatosis and fibrosis in chronic hepatitis c (chc). the g allele of the mtp gene promoter, -493g/t, has been associated with lower transcriptional activity than the t allele. we investigated this association with metabolic and histological variables in patients with chc. a total of 174 untreated patients with chc were genotyped for mtp -493g/t by direct sequencing using pcr. all patients were negative for markers of wilson¡¯s disease, hemochromatosis and autoimmune diseases and had current and past daily alcohol intake lower than 100 g/week. the sample distribution was in hardy-weinberg equilibrium. among subjects with genotype 1, 56.8% of the patients with fibrosis grade 3+4 presented at least one g allele versus 34.3% of the patients with fibrosis grade 1+2 (or = 1.8; 95%ci = 1.3-2.3). logistic regression analysis with steatosis as the dependent variable identified genotypes gg+gt as independent protective factors against steatosis (or = 0.4, 95%ci = 0.2-0.8; p = 0.01). the results suggest that the presence of the g allele of mtp -493g/t associated with lower hepatic mtp expression protects against steatosis in our chc patients.
%K hepatitis c
%K steatosis
%K fibrosis
%K microsomal transfer protein.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0100-879X2012000100012&lng=en&nrm=iso&tlng=en