%0 Journal Article
%T Tumor-Associated Macrophages Recruit CCR6+ Regulatory T Cells and Promote the Development of Colorectal Cancer via Enhancing CCL20 Production in Mice
%A Jinlin Liu
%A Ning Zhang
%A Qun Li
%A Weiwei Zhang
%A Fang Ke
%A Qibin Leng
%A Hong Wang
%A Jinfei Chen
%A Honglin Wang
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0019495
%X Tumor-associated macrophages (TAMs) remodel the colorectal cancer (CRC) microenvironment. Yet, findings on the role of TAMs in CRC seem to be contradictory compared with other cancers. FoxP3+ regulatory T (Treg)-cells dominantly infiltrate CRC. However, the underlying molecular mechanism in which TAMs may contribute to the trafficking of Treg-cells to the tumor mass remains unknown.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0019495