%0 Journal Article
%T Functional Alteration of a Dimeric Insecticidal Lectin to a Monomeric Antifungal Protein Correlated to Its Oligomeric Status
%A Nilanjana Banerjee
%A Subhadipa Sengupta
%A Amit Roy
%A Prithwi Ghosh
%A Kalipada Das
%A Sampa Das
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0018593
%X Allium sativum leaf agglutinin (ASAL) is a 25-kDa homodimeric, insecticidal, mannose binding lectin whose subunits are assembled by the C-terminal exchange process. An attempt was made to convert dimeric ASAL into a monomeric form to correlate the relevance of quaternary association of subunits and their functional specificity. Using SWISS-MODEL program a stable monomer was designed by altering five amino acid residues near the C-terminus of ASAL.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0018593