%0 Journal Article
%T Chronic Delivery of Antibody Fragments Using Immunoisolated Cell Implants as a Passive Vaccination Tool
%A Osiris Marroquin Belaunzaran
%A Maria Isabel Cordero
%A Veronica Setola
%A Siro Bianchi
%A Carmela Galli
%A Nicolas Bouche
%A Vladimir Mlynarik
%A Rolf Gruetter
%A Carmen Sandi
%A Jean-Charles Bensadoun
%A Maurizio Molinari
%A Patrick Aebischer
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0018268
%X Monoclonal antibodies and antibody fragments are powerful biotherapeutics for various debilitating diseases. However, high production costs, functional limitations such as inadequate pharmacokinetics and tissue accessibility are the current principal disadvantages for broadening their use in clinic.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0018268