%0 Journal Article
%T Characterization of a Human Cell Line Stably Over-Expressing the Candidate Oncogene, Dual Specificity Phosphatase 12
%A Erica L. Cain
%A Sterling E. Braun
%A Alexander Beeser
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0018677
%X Analysis of chromosomal rearrangements within primary tumors has been influential in the identification of novel oncogenes. Identification of the ˇ°driverˇ± gene(s) within cancer-derived amplicons is, however, hampered by the fact that most amplicons contain many gene products. Amplification of 1q21¨C1q23 is strongly associated with liposarcomas and microarray-based comparative genomic hybridization narrowed down the likely candidate oncogenes to two: the activating transcription factor 6 (atf6) and the dual specificity phosphatase 12 (dusp12). While atf6 is an established transcriptional regulator of the unfolded protein response, the potential role of dusp12 in cancer remains uncharacterized.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0018677