%0 Journal Article
%T Clinical presentation and follow up of children with congenital toxoplasmosis in Brazil
%A S¨˘fadi
%A Marco A. P.
%A Berezin
%A Eitan N.
%A Farhat
%A Calil K.
%A Carvalho
%A Eduardo S.
%J Brazilian Journal of Infectious Diseases
%D 2003
%I Brazilian Society of Infectious Diseases
%R 10.1590/S1413-86702003000500007
%X we evaluated the clinical presentation and determined the ocular and neurologic sequelae in children with congenital toxoplasmosis in brazil, taking into consideration the shortage of national publications on this disease. follow-up evaluations were made of 43 children with congenital toxoplasmosis referred to santa casa de s£żo paulo, during a period of at least five years. selection of the cases was based in clinical and laboratory criteria. a clear predominance of children with subclinical presentation of the disease at birth (88%) was found. of the 43 children, 22 (51%) developed neurological manifestations. using skull radiography, we detected neuroradiologic alterations in seven children (16%) and with tomography in 33 children (77%). neurological sequelae were identified in 15 children (54%) in the group with cerebral calcifications and in 7 (47%) in the group without cerebral calcifications. we observed chorioretinitis in 95% of the cases. reactivation of cicatricial lesions and the emergence of new ocular lesions were observed in five cases. the most frequent neurological manifestation was a delay in neuropsychomotor development. most remarkable was the finding that cerebral calcifications were not associated with a higher incidence of neurological sequelae among the children. chorioretinitis was the main ocular sequel of the infection, found in nearly all children; it can manifest years from birth, even in children submitted to specific therapy during the first year of life, highlighting the importance of a follow-up of these children.
%K congenital toxoplasmosis
%K chorioretinitis
%K neurologic manifestation.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1413-86702003000500007&lng=en&nrm=iso&tlng=en