%0 Journal Article
%T Serotonin transporter gene polymorphisms: a case-control study
%A Abdo
%A Evandro Neves
%A Correia-Silva
%A Jeane de F¨¢tima
%A Gomes
%A Carolina Cavali¨¦ri
%A Pordeus
%A Isabela Almeida
%A Gomez
%A Ricardo Santiago
%J Brazilian Dental Journal
%D 2012
%I Dental Foundation of Ribeir?o Preto
%R 10.1590/S0103-64402012000100012
%X considerable evidence indicates that serotonergic mechanisms, particularly the serotonin transporter, are involved in alcoholism and tobacco use and are influenced by polymorphism of the promoter region of 5htt (5-httlpr). as alcohol and tobacco consumption have been implicated in the pathogenesis of oral cancer, the purpose of this study was to investigate 5-httlpr polymorphism in patients with oral squamous cell carcinoma (oscc) compared with a control group in a sample of brazilian patients. one hundred and three patients affected by oscc and 103 volunteers without oscc were genotyped for 5-httlpr. both groups were matched for age, sex and tobacco use. the chi-squared test was used for statistical analysis (¦Á=0.05). there was no statistically significant difference in 5-httlpr genotypes between case and control group (p= 0.408). in conclusion, the present investigation demonstrated that serotonin transporter polymorphisms are not implicated in the ossc development.
%K oral squamous cell carcinoma
%K 5-httlpr
%K polymorphism.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-64402012000100012&lng=en&nrm=iso&tlng=en