%0 Journal Article
%T Effects of a novel calcium aluminate cement on the early events of the progression of osteogenic cell cultures
%A Castro-Raucci
%A Larissa Moreira Spinola de
%A Oliveira
%A Ivone Regina de
%A Teixeira
%A Lucas Novaes
%A Rosa
%A Adalberto Luiz
%A Oliveira
%A Paulo Tambasco de
%A Jacobovitz
%A Marcos
%J Brazilian Dental Journal
%D 2011
%I Dental Foundation of Ribeir?o Preto
%R 10.1590/S0103-64402011000200002
%X the present study evaluated the progression of osteogenic cell cultures exposed to a novel calcium aluminate cement (cac+) in comparison with the gold standard mineral trioxide aggregate (mta). cells were enzimatically isolated from newborn rat calvarial bone, plated on glass coverslips containing either cac+ or a control mta samples in the center, and grown under standard osteogenic conditions. over the 10-day culture period, roundening of sample edges was clearly noticed only for mta group. although both cements supported osteogenic cell adhesion, spreading, and proliferation, cac+-exposed cultures showed significantly higher values in terms of total cell number at days 3 and 7, and total protein content and alkaline phosphatase activity at day 10. the present in vitro results indicate that the exposure to cac+ supports a higher differentiation of osteogenic cells compared with the ones exposed to mta. further experimental studies should consider cac+ as a potential alternative to mta when the repair of mineralized tissues is one of the desired outcomes in endodontic therapy.
%K calcium aluminate cement
%K mineral trioxide aggregate
%K cell culture
%K osteoblast
%K alkaline phosphatase.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-64402011000200002&lng=en&nrm=iso&tlng=en