%0 Journal Article
%T Ordered mesoporous silica carrier system applied in nanobiothecnology
%A Sousa
%A Andreza de
%A Sousa
%A Ed¨¦sia Martins Barros de
%J Brazilian Archives of Biology and Technology
%D 2005
%I Tecpar
%R 10.1590/S1516-89132005000700036
%X ordered mesoporous materials like sba15 possess a network of channels and pores of well-defined size in the nanoscale range (2-50 nm). this particular pore architecture makes them suitable candidates for hosting and delivery under appropriate conditions of a variety of molecules of pharmaceutical interest, including radiopharmaceuticals. the characteristics of sba-15 prepared in different temperatures and the behavior of this system regarding microencapsulation of a model drug were investigated. the calcined samples were formed in 0.2 g disks and were soaked in a solution of atenolol used as a model drug. the modification of the aging temperature provoked changes in the structure of the pores, indicating the presence of microporosity and connections between mesopores. aging the materials at a higher temperature resulted in no microporosity and this fact influenced the control of the release of the model drug.
%K mesoporous materials
%K drug delivery system
%K cancer treatment
%K sba15.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1516-89132005000700036&lng=en&nrm=iso&tlng=en