%0 Journal Article
%T Preparation of pellets containing highly soluble drug by extrusion/spheronisation and coating with Kollicoat£¿ SR 30D
%A Andreazza
%A Itamar Francisco
%A Ferraz
%A Humberto Gomes
%J Brazilian Archives of Biology and Technology
%D 2011
%I Tecpar
%R 10.1590/S1516-89132011000200013
%X the aim of this study was to prepare and evaluate the pellets, containing a highly soluble drug (ascorbic acid), by the extrusion-spheronization process and coated with a release controlling polymer. the coating (undertaken in a fluid bed) was applied to three batches of the pellets with a dispersion of kollicoat£¿ sr 30 d, with each batch of pellets receiving a different level of polymer (5.07; 8.26 and 10.35%). the coated pellets were evaluated for sphericity by imaging analysis and comparative dissolution profile with a product commercially available in brazil. all of the evaluated samples presented adequate physical properties and the dissolution profile of those coated with 5.07% of polymer proved to be similar to that of the commercially available brand name.
%K coating
%K pellets
%K extrusion spheronization
%K controlled release.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1516-89132011000200013&lng=en&nrm=iso&tlng=en