%0 Journal Article
%T Improved Survival of HIV-1-Infected Patients with Progressive Multifocal Leukoencephalopathy Receiving Early 5-Drug Combination Antiretroviral Therapy
%A Jacques Gasnault
%A Dominique Costagliola
%A Houria Hendel-Chavez
%A Anne Dulioust
%A Sophie Pakianather
%A Anne-Aur¨¦lie Mazet
%A Marie-Ghislaine de Goer de Herve
%A R¨¦mi Lancar
%A Anne-Sophie Lascaux
%A Lydie Porte
%A Jean-Fran£¿ois Delfraissy
%A Yassine Taoufik
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0020967
%X Progressive multifocal leukoencephalopathy (PML), a rare devastating demyelinating disease caused by the polyomavirus JC (JCV), occurs in severely immunocompromised patients, most of whom have advanced-stage HIV infection. Despite combination antiretroviral therapy (cART), 50% of patients die within 6 months of PML onset. We conducted a multicenter, open-label pilot trial evaluating the survival benefit of a five-drug cART designed to accelerate HIV replication decay and JCV-specific immune recovery.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0020967