%0 Journal Article
%T An Engineered Viral Protease Exhibiting Substrate Specificity for a Polyglutamine Stretch Prevents Polyglutamine-Induced Neuronal Cell Death
%A Saravanan Sellamuthu
%A Bae Hyun Shin
%A Hye-Eun Han
%A Sang Min Park
%A Hye Jin Oh
%A Seong-Hwan Rho
%A Yong Jae Lee
%A Woo Jin Park
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0022554
%X Polyglutamine (polyQ)-induced protein aggregation is the hallmark of a group of neurodegenerative diseases, including Huntington's disease. We hypothesized that a protease that could cleave polyQ stretches would intervene in the initial events leading to pathogenesis in these diseases. To prove this concept, we aimed to generate a protease possessing substrate specificity for polyQ stretches.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0022554