%0 Journal Article
%T Serum Methionine Metabolites Are Risk Factors for Metastatic Prostate Cancer Progression
%A Sally Stabler
%A Tatsuki Koyama
%A Zhiguo Zhao
%A Magaly Martinez-Ferrer
%A Robert H. Allen
%A Zigmund Luka
%A Lioudmila V. Loukachevitch
%A Peter E. Clark
%A Conrad Wagner
%A Neil A. Bhowmick
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0022486
%X Clinical decision for primary treatment for prostate cancer is dictated by variables with insufficient specificity. Early detection of prostate cancer likely to develop rapid recurrence could support neo-adjuvant therapeutics and adjuvant options prior to frank biochemical recurrence. This study compared markers in serum and urine of patients with rapidly recurrent prostate cancer to recurrence-free patients after radical prostatectomy. Based on previous identification of urinary sarcosine as a metastatic marker, we tested whether methionine metabolites in urine and serum could serve as pre-surgical markers for aggressive disease.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0022486