%0 Journal Article
%T Polimorfismo gen¨¦tico de la apolipoprote¨ªna E en un grupo de escolares del centro-oriente colombiano: comparaci¨®n con las concentraciones plasm¨¢ticas de l¨ªpidos y apolipoprote¨ªnas
%A Callas
%A Ney
%A Poveda
%A Elpidia
%A Baracaldo
%A C¨¦sar
%A Hern¨¢ndez
%A Patricia
%A Castillo
%A Carlina
%A Guerra
%A Martha
%J Biom¨¦dica
%D 2007
%I Instituto Nacional de Salud
%X introduction. research in laboratories around the world has documented the contribution of the e apolipoprotein alleles to structural variations of lipids and apolipoproteins. objective. the gene frequencies of the e apolipoprotein alleles were compared with the lipid and apolipoprotein levels in school age children. materials and methods. six hundred and ninety one 5 to 15 years old school age children from the colombian departments of cundinamarca, boyac¨¢, meta, santander and norte de santander, were evaluated.the genotypes of the e apolipoprotein were identified by polymerase chain reaction-restriction fragment length polymorphism. plasma levels for the following 5 lipids and lipoproteins were assayed: total cholesterol, hdl (high density lipoprotein) cholesterol, ldl (low density lipoprotein) cholesterol, triglycerides, vldl (very low density lipoprotein) cholesterol, a-i apolipoprotein and b-100 apolipoprotein. results. alleles ¦Å2, ¦Å3 and ¦Å4 were found in frequencies of 0.04, 0.86 and 0.08, respectively. the e4 group (e4/3-e4/4), in contrast with the e2 group (e3/2-e2/2), presented highest plasma concentrations of total cholesterol, ldl cholesterol and b-100 apolipoprotein (p=0.014, 0.001 and 0.000, respectively). when the e3/3 group was compared with e2, the same result was obtained (p=0.015, 0.002 and 0.002, respectively). the influence of the e apolipoprotein polymorphism appeared greater in female children than male. conclusions. the e4 allele was associated with higher levels of total cholesterol, ldl cholesterol and b-100 apolipoprotein and indicates the necessity of additional research into the interactions between polymorphism e apolipoprotein and other genes, life styles, risk factors and potential contribution to cardiovascular diseases.
%K polymorphism
%K genetic
%K apolipoproteins
%K cholesterol
%K triglycerides
%K child
%K adolescent.
%U http://www.scielo.org.co/scielo.php?script=sci_abstract&pid=S0120-41572007000400008&lng=en&nrm=iso&tlng=en