%0 Journal Article %T Wnt signaling: A complex issue %A HENDRIKS %A BART %A REICHMANN %A ERNST %J Biological Research %D 2002 %I Sociedad de Biolog¨ªa de Chile %R 10.4067/S0716-97602002000200019 %X the development of tissues and organs in multicellular organisms is controlled by the interplay of several signaling pathways that cross-talk to provide positional information and induce cell fate specification. together with other families of secreted factors such as tgf£¿s, fgfs, hedgehog and notch proteins, wnt growth factors are crucially implicated in these processes. here, we will first discuss molecular mechanisms and then consider some biological consequences of wnt signaling %K wnts %K frizzled %K lrp 5/6 %K £¿-catenin %K apc %K tcf. %U http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0716-97602002000200019&lng=en&nrm=iso&tlng=en