%0 Journal Article
%T Positive effects of Green Tea on hepatic dysfunction, lipid peroxidation and antioxidant defence depletion induced by cadmium
%A HAMDEN
%A KHALED
%A CARREA U
%A SERGE
%A AYADI MARKI
%A FATMA
%A MASMOUDI
%A HATEM
%A EL FEKI
%A ABDELFATTAH
%J Biological Research
%D 2008
%I Sociedad de Biolog¨Şa de Chile
%R 10.4067/S0716-97602008000300009
%X cadmium (cd) is a highly toxic environmental and industrial cumulative pollutant that affeets many organs, especially the liver. the present study was designed to eval¨²ate the antioxidant effect of green tea on cadmium-induced hepatic dysfunction and oxidative stress in rats. adult male wistar rats were administered cadmium by injection of 20 emoles /kg bw/ every 3 days for six months. this study revealed significant (p < 0.05) liver dysfunction, lipid peroxidation and a decline in antioxidant enzyme activities in the liver of cadmium-treated rats compared to control anim¨˘is. compared to control rats, the activities of lactate dehydrogenase (ldh), gammaglutamyl transferase (ggt), acid phosphatase (pac), phosphatase alkaline (pal), as well as bilirubin and thiobarbituric acid-reactive substances (tbars), were significantly (p < 0.05) increased in cd-treated rats. moreover, antioxidant enzyme activities, such as superoxide dismutase (sod), glutathione peroxidase (gpx) and catalase, were significantly (p < 0.05) decreased in the liver of cadmium-treated rats. the oral administration of 5% aqueous green tea extract, along with cadmium treatment for six months, caused a significant (p < 0.05) improvement in cadmium-induced toxicity by significantly decreasing (p < 0.05) the activities of enzymatic markers of liver dysfunction (ldh, ggt, pac, pal activities, as well as the bilirubin rate). indeed, green tea extract significantly increased (p < 0.05) antioxidant enzymatic activities (sod, catalase, gpx) in rat liver, compared to those given cadmium alone. thus, the oral administration of green tea, along with cadmium significantly (p < 0.05) improves cadmium-induced liver dysfunction and stress oxidant in rats' liver.
%K cadmium
%K rat liver dysfunction
%K green tea
%K antioxidant enzymes
%K lipid peroxidation.
%U http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0716-97602008000300009&lng=en&nrm=iso&tlng=en