%0 Journal Article
%T Avalia£¿£¿o plasm¨¢tica de igf-1 no prolactinoma
%A Zylberberg
%A Daniela
%A Naliato
%A Erika C.O.
%A Sarmet
%A Alair
%A Sato
%A Eduardo
%A Costa
%A Fernando S.R.
%A Violante
%A Alice H.D.
%J Arquivos de Neuro-Psiquiatria
%D 2006
%I Academia Brasileira de Neurologia - ABNEURO
%R 10.1590/S0004-282X2006000500026
%X prolactinomas are the most frequent pituitary tumors and may co-secrete gh (growth hormone). igf-1 (insulin-like growth factor-1) is the main responsible for gh actions and a parameter for the diagnosis of acromegaly. with the objective of identifying through a igf-1 levels analysis, in the initial evaluation of prolactinoma patients, the existence of mixed tumors [gh and prolactin (prl)], we studied 7 men and 27 women, aged between 19 and 72 years, confronting them with the results of basal and glucose stimulated (glucose tolerance test - gtt) gh levels, indicated when gh >0.4 ng/ml or igf-1 levels were elevated. the prevalence of patients with gh >0.4 ng/ml and elevated igf-1 was higher than expected; however, after gtt, no patient fulfilled the diagnostic criteria for acromegaly. however, we suggest that, they should be submitted to igf-1 evaluation, due to the risk of gh co-secretion in prolactinomas. special attention should be paid to those who present a significant decrease of prl levels without concomitant tumor size reduction.
%K insulin-like growth factor-1
%K hyperprolactinemia
%K prolactinoma
%K acromegaly.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-282X2006000500026&lng=en&nrm=iso&tlng=en