%0 Journal Article
%T Toxic myopathies: muscle biopsy features
%A Scola
%A Rosana Herminia
%A Pereira
%A Eduardo Rafael
%A Lorenzoni
%A Paulo Jos¨¦
%A Werneck
%A Lineu C¨¦sar
%J Arquivos de Neuro-Psiquiatria
%D 2007
%I Academia Brasileira de Neurologia - ABNEURO
%R 10.1590/S0004-282X2007000100018
%X several drugs and toxic substances can cause muscular abnormalities and are frequent causes of acquired myopathies. we present a series of 32 patients, predominance of young adult patients, diagnosed with toxic myopathy. the most common substances inducing myopathy were corticosteroids (56.2%) followed by the propoxyphene, neuroleptics, zidovudine and drug-induced hypokalemia. the investigation showed normal serum creatine kinase levels in 65.4%, myopathic pattern of the needle electromyography in 40% and the more frequent histological diagnosis of the muscle biopsy was type 2 fiber atrophy (59.3%). clinical features, etiology, course of the disease, serum levels of muscular enzymes, electromyographic features and, especially, muscle biopsy features are discussed.
%K myopathy
%K drug
%K iatrogenic myopathy
%K toxic myopathy
%K muscle biopsy.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-282X2007000100018&lng=en&nrm=iso&tlng=en