%0 Journal Article
%T Effects of subclinical hypothyroidism treatment on psychiatric symptoms, muscular complaints, and quality of life
%A Reuters
%A Vaneska Spinelli
%A Almeida
%A Cloyra de Paiva
%A Teixeira
%A Patr¨ªcia de F¨¢tima dos Santos
%A Vig¨¢rio
%A Patr¨ªcia dos Santos
%A Ferreira
%A M¨¢rcia Martins
%A Castro
%A Carmen Lucia Natividade de
%A Brasil
%A Marco Ant£¿nio
%A Costa
%A Ant£¿nio Jos¨¦ Leal da
%A Buescu
%A Alexandru
%A Vaisman
%A M¨¢rio
%J Arquivos Brasileiros de Endocrinologia & Metabologia
%D 2012
%I Sociedade Brasileira de Endocrinologia e Metabologia
%R 10.1590/S0004-27302012000200006
%X objectives: to evaluate the impact of subclinical hypothyroidism (sht) treatment on health-related quality of life (qol), psychiatric symptoms, clinical score, and muscle function. materials and methods: in this randomized double-blind study, patients were assigned either to treatment (n = 35) or placebo (n = 36). clinical and psychiatric symptoms were assessed by the zulewski, hamilton and beck scales. qol was assessed by the sf-36 questionnaire. assessments of quadriceps (qs) and inspiratory muscle (is) strength were performed by a chair dynamometer and a manuvacuometer. results: treatment improved is (+11.5 ¡À 17.2; p = 0.041), as did qol domains "pain" and "role physical" (+19.7 ¡À 15.2, 0.039 and +22.1 ¡À 47.5, p = 0.054; respectively). clinical and psychiatric symptoms showed similar responses to both interventions. conclusions: sht treatment improved is and physical aspects of qol, despite no impact in other muscle parameters. clinical score, psychiatric symptoms, and sf-36 domains, based on mental dimensions of qol may be more susceptible to "placebo effect" in patients with sht.
%K anxiety
%K depression
%K quality of life
%K levothyroxine.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-27302012000200006&lng=en&nrm=iso&tlng=en