%0 Journal Article
%T Changes in prolactin secretion in the short- and long-term after adrenalectomy
%A Laguna-Abreu
%A Maria Thereza C.
%A Germano
%A Carla
%A Moreira
%A Ayrton C.
%A Antunes-Rodrigues
%A Jos¨¦
%A Elias
%A Lucila
%A Castro
%A Margaret
%J Arquivos Brasileiros de Endocrinologia & Metabologia
%D 2012
%I Sociedade Brasileira de Endocrinologia e Metabologia
%R 10.1590/S0004-27302012000400005
%X objective: to evaluate the modulation of the hypothalamus-pituitary-adrenal axis (hpa) on prolactin secretion in rats after adrenalectomy (adx). materials and methods: plasma corticosterone, acth, and prolactin concentrations were measured by radioimmunoassay in rats after bilateral adx in the short- (3 hours and 1day) and long-term (3, 7, and 14 days). results: animals that underwent adx showed undetectable corticosterone levels and a triphasic acth response with a transient increase (3h), a decrease (1d), and further increase in the long-term after adx. sham animals showed a marked increase in corticosterone and acth levels three hours after surgery, with a decrease to basal levels thereafter. plasma prolactin levels were not changed after adx. conclusion: there are different points of equilibrium in the hpa axis after the glucocorticoid negative feedback is removed. prolactin plasma secretion is not altered in the short or long- term after adx, suggesting that the peptidergic neurons essential for prolactin release are not activated after adx.
%K adrenalectomy
%K prolactin
%K corticosterone
%K adrenocorticotropic hormone.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-27302012000400005&lng=en&nrm=iso&tlng=en