%0 Journal Article
%T Effects of Ginkgo Biloba Special Extract EGb 761® in Very Mild Cognitive Impairment (vMCI)
%A Brigitte Grass-Kapanke
%A Arija Busmane
%A Andris Lasmanis
%A Robert Hoerr
%A Reiner Kaschel
%J Neuroscience & Medicine
%P 48-56
%@ 2158-2947
%D 2011
%I Scientific Research Publishing
%R 10.4236/nm.2011.21007
%X Objective: To assess effects of EGb 761® on cognition and quality of life in subjects with very mild cognitive impair-ment. Methods: We randomized 300 subjects aged 45 to 65 with cognitive complaints and low functioning (more than one standard deviation below appropriate norm) in at least one cognitive test to double-blind treatment with once daily 240 mg EGb 761® or placebo for 12 weeks. Results: The exploratory intention-to-treat analysis showed significant im-provement (p < 0.025, one-sided) beyond practice effects for EGb 761® in a measure of attention (Vienna Test System - Work Performance Series) and trends in favour of EGb 761® in measures of memory (Wechsler Memory Scale III - Faces I, Appointments Test ¨C delayed recall), and perceived physical health (SF36 - factor score Physical Health). Cognitive effects were more pronounced and more consistent (p < 0.025 in 4 of 5 tests) in subjects with lower memory function at baseline. Specifically, practice effects in the more demanding tests were attenuated or absent in these sub-jects. Conclusion: Ginkgo biloba extract EGb 761® improved cognitive functioning and aspects of quality of life in sub-jects with very mild cognitive impairment.
%K Ginkgo Biloba
%K EGb 761&#174
%K Mild Cognitive Impairment
%K Memory
%K Concentration
%K Randomised Controlled Trial
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=4279