%0 Journal Article
%T Compara£¿£¿o de biomarcadores inflamat¨®rios entre pacientes diab¨¦ticos e n£¿o-diab¨¦ticos com angina inst¨¢vel
%A Huoya
%A Mar£¿al de Oliveira
%A Penalva
%A Rafaela Andrade
%A Alves
%A S¨ªlber Rodrigues
%A Feitosa
%A G¨ªlson Soares
%A Gadelha
%A Sandra
%A Ladeia
%A Ana Marice Teixeira
%J Arquivos Brasileiros de Cardiologia
%D 2009
%I Sociedade Brasileira de Cardiologia - SBC
%R 10.1590/S0066-782X2009000400006
%X background: studies comparing inflammatory activity between diabetic and non-diabetic individuals with acute coronary syndrome are scarce, and none including only patients with unstable angina (ua) has been published to date. objective: we compared serum c-reactive protein (crp), and interleukin-6(il-6) between diabetic and non-diabetic patients with unstable angina (ua) to determine if difference in inflammatory activity is responsible for a worse prognosis in diabetic patients. we also evaluated the correlation between inflammatory markers and the metabolic profile in diabetic patients and the correlation between inflammatory response and in-hospital outcomes: death, acute myocardial infarction, congestive heart failure, and length of stay in hospital. methods: a prospective cohort study of 90 consecutive patients admitted to a chest pain unit with ua and divided into two groups, diabetic and non-diabetic. serum crp, il-6, metabolic profile and leukocyte count were measured at hospital arrival. results: forty-two patients (47%) were diabetic (age 62¡À9) vs. 48 (53%) non-diabetic (age 63¡À12). no differences between median c-reactive protein (1.78 vs. 2.23mg/l,p=0.74) and interleukin-6 (0 vs. 0pg/ml,p=0.31) were found between the two groups. there was a positive correlation between crp and total cholesterol (rs = 0.21,p = 0.05), crp and ldl-cholesterol (rs=0.22,p=0.04) and between crp and leukocyte count (rs = 0.32, p = 0.02) in both groups. no associations were found between inflammatory markers and in-hospital outcomes. conclusion: we found no difference in inflammatory activity between diabetic and non-diabetic patients with ua, suggesting that this clinical condition may result in balanced inflammatory activity between the two groups and increase acute-phase proteins independently of metabolic state.
%K atherosclerosis [complications]
%K diabetes mellitus
%K inflammation [complications]
%K angina pectoris.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0066-782X2009000400006&lng=en&nrm=iso&tlng=en